Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast

Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast Fungi are a valuable source of enzymatic diversity and therapeutic natural products including antibiotics. Here we engineer the baker’s yeast Saccharomyces cerevisiae to produce and secrete the antibiotic penicillin, a beta-lactam nonribosomal peptide, by taking genes from a filamentous fungus and directing their efficient expression and subcellular localization. Using synthetic

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Whole-cell biocatalysts by design

Whole-cell biocatalysts by design Whole-cell biocatalysts provide unique advantages and have been widely used for the efficient biosynthesis of value-added fine and bulk chemicals, as well as pharmaceutically active ingredients. What is more, advances in synthetic biology and metabolic engineering, together with the rapid development of molecular genetic tools, have brought about a renaissance of whole-cell biocatalysis. These rapid advancements

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WE NEED TO TALK ABOUT GENE TECH: CBMNet Management Board Member Prof Susan Molyneux Hodgson

  CBMNet Management Board Member Professor Susan Molyneux Hodgson spoke at the Hay Litery festival last night in the session ‘We Need to talk about Gene Tech’. Why does public debate and policy treat the application of genetic technology differently when we are discussing medicine and food? Why is our concept of what is ‘natural’ so controversial and the idea of

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CBMNet Proof-of-Concept and Vacation Scholarship projects awarded

CBMNet Proof-of-Concept and Vacation Scholarship projects awarded Following on from our latest Proof-of-Concept and Vacation Scholarship funding calls we are pleased to announce that we have funded 6 projects. Proof-of-Concept: Newcastle University and Ingenza – L-form technologies: a novel platform for therapeutic protein production. Many human proteins are used for the treatment of a wide variety of diseases and many more

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Large scale validation of an efficient CRISPR/Cas-based multi gene editing protocol in Escherichia coli

Large scale validation of an efficient CRISPR/Cas-based multi gene editing protocol in Escherichia coli The exploitation of the CRISPR/Cas9 machinery coupled to lambda (λ) recombinase-mediated homologous recombination (recombineering) is becoming the method of choice for genome editing in E. coli. First proposed by Jiang and co-workers, the strategy has been subsequently fine-tuned by several authors who demonstrated, by using few

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£25,000 Proof-of-Concept Available

£25,000 Proof-of-Concept Available As a result of our last Proof-of-Concept call, and some under-spend, we have £25,000 of PoC funding remaining (@80%fEC). Therefore, we are inviting applications from our members for a final PoC project. Details: To allow consortia to generate the preliminary information required to establish the feasibility of their proposed approaches, with the target of generating competitive bids to

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CBMNet goes International

We are pleased to announce that we have successfully been awarded funding from the BBSRC to expand CBMNet activities across the globe! We are headed to New Zealand for a workshop aimed at ‘Exploiting Algae and marine biomass for Industrial Biotechnology and Bioenergy’ In August 2017, CBMNet and PHYCONET members are heading to the Cawthron Institute, Nelson, New Zealand. The workshop focuses

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Microbial response to environmental stresses: from fundamental mechanisms to practical applications

Microbial response to environmental stresses: from fundamental mechanisms to practical applications Environmental stresses are usually active during the process of microbial fermentation and have significant influence on microbial physiology. Microorganisms have developed a series of strategies to resist environmental stresses. For instance, they maintain the integrity and fluidity of cell membranes by modulating their structure and composition, and the permeability

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Improved n-butanol production via co-expression of membrane-targeted tilapia metallothionein and the clostridial metabolic pathway in Escherichia coli

Improved n-butanol production via co-expression of membrane-targeted tilapia metallothionein and the clostridial metabolic pathway in Escherichia coli Background N-Butanol has favorable characteristics for use as either an alternative fuel or platform chemical. Bio-based n-butanol production using microbes is an emerging technology that requires further development. Although bio-industrial microbes such as Escherichia coli have been engineered to produce n-butanol, reactive oxygen

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CBMNet Sponsored Early Career Researcher wins Gordon Conference ‘Best Oral Presentation’ Prize

      CBMNet Sponsored Early Career Researcher wins Gordon Conference ‘Best Oral Presentation’ Prize We are pleased to announce that CBMNet member Arthur Neuberger, University of Cambridge, has just returned from the Gordon Conference on ‘Multi-Drug Efflux Systems’, where he won 1st Prize for ‘Best Oral Presentation’. CBMNet sponsored him through one of our Early Researcher Grants to attend

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