CBMNet Event: Factories for advanced biomanufacturing

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Date/Time
Date(s) - 06/12/2017 - 07/12/2017
All Day

Location
Halifax Hall Hotel


CBMNet Event: Factories for advanced biomanufacturing

This 2 day FREE event will bring together academic scientists with diverse interests in microbial chassis engineering, alongside industrial scientists who are interested in improving the robustness of whole-cell biocatalysts to overcome restrictions on product titres, separability, sustainability and process economics. Key themes for the event will address six major challenges in chassis design:

  • Reverse-engineering of microbial chassis, where the manufacturing process is designed first, and the biocatalyst is developed to match the process constraints
  • Tolerance to toxic products and substrates, to overcome current restrictions on product titres
  • Improved strain stability for continuous manufacturing, to achieve the productivity critical for bio-based bulk chemicals manufacturing
  • Improved atom efficiency, to enable efficient conversion of substrate to product without loss of carbon, by diverting fluxes away from cell growth towards product and minimizing by-product formation
  • Improved transport processes, to ensure efficient substrate uptake and product efflux
  • Innovative high throughput tools for systems metabolic engineering, including CRISPR-Cas,  integrase technology, directed evolution, high-throughput screening and selection.

Registration and accommodation and dinner for the evening of December 6th are FREE. Limited spaces available, so register now! **CLICK HERE**

Draft Agenda:

Factories for Advanced Biomanufacturing, 6-7 December 2017
Time Title Person
Wednesday December 6th
10:00 Registration
10:15 Welcome
10:30 Developing disruptive bio-based processes Adriana Botes, VideraBio
Improved Transport Processes
11:15 TBC TBC
11:45 A functional model of the Gram-positive bacterial Signal Recognition Particle and potential biotechnological applications Colin Harwood, University of Newcastle
12:05 Flash Presentation: Yeast carboxylate transporters and its potential application in the biotechnological industry Isabel Silva, Universidade do Minho
12:15 Flash Presentation@ The difficulty of cell penetration of lipophilic substrates Matthew Hodges, Oxford Biotrans
12:25 Flash Presentation: Rubbish to resource: Growing microbes on municipal solid waste Aritha Dornau, University of York
12:35 Flash Presentation: Export of Disulphide bonded proteins via Tat secretion system in E.coli Isabel Guerrero Montero, University of Kent
12:45 Flash Presentation: Engineering glucan polymer uptake, production and efflux Christian Voigt, University of Sheffield
12:55 Lunch
Product Tolerance
14:00 TBC TBC
14:30 Improving clostridia tolerance to n-butanol Holly Smith, Green Biologics
15:00 Flash Presentation: Microbial resistance to chlorhexidine Peter Henderson, University of Leeds
15:10 Flash Presentation TBC
15:20 Flash Presentation TBC
15:30 Coffee
Strain Stability
16:00 Genetic stability for continuous chemicals production in bacterial fermentation Dr James Allen, UCL
16:30 Improving microbial factories robustness using bacteriocins Phillipe Gabant, Syngulon
17:00 Strain development and spore manufacture (for microbiome applications) Edward Green, CHAIN Biotech
17:10 Flash presentation: Improving lutein production in microalgae – a genetic engineering approach Josie McQuillan, University of Sheffield
17:20 Flash Presentation: Engineering Cupriavidus and Cyanobacteria for Improved Production of High Value Chemicals Samantha Bryan, University of Nottingham
 17:30 Flash Presentation: Manipulating the E. coli cytoplasm for the stable production of disulphide bonded bio therapeutics Kirsty Richards, University of Kent
 17:40 Round up of the day Jeff Green, University of Sheffield
18:30 Networking Drinks and Poster Session
Poster:  A model for the functioning of the Gram-positive bacterial Signal Recognition Particle Colin Harwood, Newcastle University
Poster: Chassis engineering for monoterpenoid production Gajendar Reddy, University of Manchester
Poster: Metabolic Evolution of CHO Cells Alejandro Fernandez-Martell, University of Sheffield
Poster: Metabolic engineering of Saccharomyces cerevisiae for xylose fermentation for bioethanol production Farnaz Yusuf,  International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi
Poster: Enzyme Engineering to Improve Ethylene Production in Cupriavidus necator Alexander Van Hagen, University of Nottingham
Poster: Towards photosynthetic hydrogen production Sean Craig, University of Nottingham
Poster: Selection technology: from R&D tools via pharma to bio-industry applications Phillipe Gabant, Syngulon
Poster: Development of Genome Engineering tools for Cupriavidus strains Sophie Vaud, University of Nottingham
Poster: Engineering Cupriavidus metallidurans towards acetaldehyde production Vera Salgado, University of Nottingham
Poster: Potential of Extremophilic enzymes in biotechnology Roumiana Todorova, Bulgarian Academy of Sciences
Poster: Metabolic engineering to improve ethylene production in Cupriavidus necator Raj Patel, University of Nottingham
Poster: Manipulating the E. coli cytoplasm for the stable production of disulphide bonded bio therapeutics Kirsty Richards, University of Kent
Poster:  Impact of Microbial transporters on advanced biofuels and biochemical generations Dipankar Ghosh, ICL
Poster:  Export of Disulphide bonded proteins via Tat secretion system in E.coli Isabel Guerrero Montero, University of Kent
Poster: Bio-ethylene production using plant pathway in Cupriavidus spp. Pierre Reitzer, University of Nottingham
Poster: Metabolic engineering of Cupriavidus necator H16 for production of platform chemicals Katalin Kovacs, University of Nottingham
19:30 Networking Dinner
Thursday December 7th
08:45 Welcome
Atom efficient Pathways
09:00 TBC TBC
09:30 Machine-learning driven analysis and optimisation of metabolic networks Claudio Angione, University of Teesside
09:50 Flash Presentation: Metabolic engineering of Saccharomyces cerevisiae for xylose fermentation for bioethanol production Farnaz Yusuf,  International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi
10:00 Flash Presentation: A rapid pathway design and optimisation pipeline for chemical production in bacteria Adrian Jervis, University of Manchester
 10:10 Flash Presentation: Genome-scale metabolic models as platforms for construction of microbial proof-of-principle strains to direct new biological discovery in the field of industrial Biotechnology Bashir Sajo Mienda, Federal University Dutse, Nigeria
 10:20 Flash Presentation: Metabolic engineering of microbes Jags Pandhal, University of Sheffield
10:30 Flash presentation: Biotech Platform for Xylitol Production – A Tale of Metabolic Engineering and Intracellular Redox Balance Abhishek Somani, Aberystwyth University
10:40 Coffee
Bioprocess Design
11:30 Bioprocess design: Bio-based methacrylates Gill Stephens, University of Nottingham
11:50 Increased UK capacity for protein production and current technical challenges Stuart West, Biocatalysts
12:10 Microbial production of Flavour and Fragrance isoprenoids Georg Lentzen, Isobionics BV
12:20 Flash Presentation: Exploration Yeasts as cell factories for production of add-value carboxylic acids and derivatives Nuno Mira, University of Lisbon
 12:30 Flash Presentation: Design of mammalian cell factories by direct evolution Alejandro Fernandez-Martell, University of Sheffield
 12:40 Flash Presentation: Developing yeast strains for biofuel production Naseem Guar, International Centre for Genetic Engineering and Biotechnology, India
12:50 Flash Presentation: Engineering bacteria for isoprene biosynthesis Naglis Malys, University of Nottingham
13:00 Lunch
Technologies for rapid cell factory engineering
13:45 Technologies for rapid cell factory engineering John Heap, ICL
14:15 Development of a thermostable CRISPR-Cas9 system for engineering of thermophiles Gudmundur Oli Hreggvidsson, Matis
14:45 Flash Presentation: Serine Integrase Recombinational Assembly (SIRA) for rapid multipart DNA assembly and rearrangement Femi Olorunniji, Liverpool John Moores University
14:55 Flash Presentation: The importance of information technology in bio-manufacturing Richard Kitney, Imperial College London
LCA, Techno-economic feasability, RRI
15:05 Technical, economic, and environmental perspectives when producing bioased products Jon McKechnie, University of Nottingham
15:35  Responsible Research and Innovation TBC
15:55 Flash Presentation: Business services for SMEs in the bioeconomy: BioBase4SME and SuperBIO Lucy Montgomery, NNFCC
16:00 Close