CBMNet Event: Factories for advanced biomanufacturing

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Date/Time
Date(s) - 06/12/2017 - 07/12/2017
All Day

Location
Halifax Hall Hotel


CBMNet Event: Factories for advanced biomanufacturing

This 2 day FREE event will bring together academic scientists with diverse interests in microbial chassis engineering, alongside industrial scientists who are interested in improving the robustness of whole-cell biocatalysts to overcome restrictions on product titres, separability, sustainability and process economics. Key themes for the event will address six major challenges in chassis design:

  • Reverse-engineering of microbial chassis, where the manufacturing process is designed first, and the biocatalyst is developed to match the process constraints
  • Tolerance to toxic products and substrates, to overcome current restrictions on product titres
  • Improved strain stability for continuous manufacturing, to achieve the productivity critical for bio-based bulk chemicals manufacturing
  • Improved atom efficiency, to enable efficient conversion of substrate to product without loss of carbon, by diverting fluxes away from cell growth towards product and minimizing by-product formation
  • Improved transport processes, to ensure efficient substrate uptake and product efflux
  • Innovative high throughput tools for systems metabolic engineering, including CRISPR-Cas,  integrase technology, directed evolution, high-throughput screening and selection.

**REGISTRATION IS NOW CLOSED! Please email jen.vanderhoven@shef.ac.uk to be placed on the reserve list.**

Agenda:

Time Title Person
Wednesday December 6th
10:00 Registration
10:15 Welcome Jeff Green, University of Sheffield
10:30 Developing disruptive bio-based processes Adriana Botes, VideraBio
Session One: Improved Transport Processes
11:15 Understanding and optimising transport of hemicellulose-derived nutrients for industrial biotechnology & bioenergy Gavin Thomas, University of York
11:45 A functional model of the Gram-positive bacterial Signal Recognition Particle and potential biotechnological applications Colin Harwood, University of Newcastle
12:05 Flash Presentation: Productive bioconversion of hydrophobic substrates Matthew Hodges, Oxford Biotrans Limited
12:13 Flash Presentation: Rubbish to resource: Growing microbes on municipal solid waste Aritha Dornau, University of York
12:21 Flash Presentation: Engineering glucan polymer uptake, production and efflux Christian Voigt, University of Sheffield
12:30 Lunch
Session Two: Product Tolerance
14:00 Multi-omics approaches for understanding and mitigating product toxicity Dave Kelly, University of Sheffield
14:30 Sustainable production of bio-n-butanol: From lab bench to commercial plant Holly Smith, Green Biologics
15:00 Flash Presentation: Microbial resistance to chlorhexidine Peter Henderson, University of Leeds
15:10 Coffee
Session Three: Strain Stability
16:00 Genetic stability for continuous chemicals production in bacterial fermentation Dr James Allen, UCL
16:30 New applications in industrial microbiology a driver for the development of new genetic control of microbial strains Phillipe Gabant, Syngulon
17:00 Strain development and spore manufacture (for microbiome applications) Daniela Heeg, CHAIN Biotech
17:10 Flash presentation: Improving lutein production in microalgae – a genetic engineering approach Josie McQuillan, University of Sheffield
17:18 Flash Presentation: Engineering Cupriavidus and Cyanobacteria for Improved Production of High Value Chemicals Samantha Bryan, University of Nottingham
17:25 Flash Presentation: Phosphite utilisation as a selective marker in bacteria Andrew Hitchcock, University of Sheffield
17:33 Round up of the day Jeff Green, University of Sheffield
Session Four: Poster Presentations
18:30 Networking Drinks and Poster Session
1 Poster:  A model for the functioning of the Gram-positive bacterial Signal Recognition Particle Colin Harwood, Newcastle University
2 Poster: Chassis engineering for monoterpenoid production Gajendar Reddy, University of Manchester
3 Poster: Metabolic Evolution of CHO Cells Alejandro Fernandez-Martell, University of Sheffield
4 Poster: Metabolic engineering of Saccharomyces cerevisiae for xylose fermentation for bioethanol production Farnaz Yusuf, ICGEB, New Delhi
5 Poster: Enzyme Engineering to Improve Ethylene Production in Cupriavidus necator Alexander Van Hagen, University of Nottingham
6 Poster: Towards photosynthetic hydrogen production Sean Craig, University of Nottingham
8 Poster: Development of Genome Engineering tools for Cupriavidus strains Sophie Vaud, University of Nottingham
9 Poster: Engineering Cupriavidus metallidurans towards acetaldehyde production Vera Salgado, University of Nottingham
10 Poster: Potential of Extremophilic enzymes in biotechnology Roumiana Todorova, Bulgarian Academy of Sciences
11 Poster: Metabolic engineering to improve ethylene production in Cupriavidus necator Raj Patel, University of Nottingham
12 Poster:  Impact of Microbial transporters on advanced biofuels and biochemical generations Dipankar Ghosh, ICL
13 Poster: Bio-ethylene production using plant pathway in Cupriavidus spp. Pierre Reitzer, University of Nottingham
14 Poster: Metabolic engineering of Cupriavidus necator H16 for production of platform chemicals Katalin Kovacs, University of Nottingham
15 Poster: The genetic basis of 3-hydroxypropanoate metabolism in Cupriavidus necator H16 Christian  Arenas, University of Nottingham
16 Poster: Optimising Triterpenoid Production in Saccharomyces cerevisiae Matthew Dale, University of Edinburgh
17 Poster: Engineering Cupriavidus necator for the production of 1,3-butanediol using synthetic metabolic pathways Joshua Gascoyne, University of Nottingham
18 Poster: The use of M. psychrotolerans as an alternative chassis for bio-manufacturing Nikolaos Pantidos, University of Edinburgh
19 Poster: Rubbish to resource: growing Escherichia coli on municipal solid waste Aritha Dornau, University of York
20 Poster: Project DETOX: detoxifying bio-based production Joyce Bennett, University of York
19:30 Networking Dinner
Thursday December 7th
08:30 Welcome Gavin Thomas, University of York
08:45 Next Generation Tools for Rapid Biomanufacturing Mike Lynch, Duke University, North Carolina
Session Five: Atom efficient Pathways
09:30 Negative carbon in bio-based substrate conversions into sustainably produced chemicals Philip Weyrauch, Ingenza
10 Machine-learning driven analysis and optimisation of metabolic networks Claudio Angione, University of Teesside
10.2 Flash Presentation: Metabolic engineering of Saccharomyces cerevisiae for xylose fermentation for bioethanol production Farnaz Yusuf, ICGEB, New Delhi
10.28 Flash Presentation: A rapid pathway design and optimisation pipeline for chemical production in bacteria Adrian Jervis, University of Manchester
10.36 Flash Presentation: Genome-scale metabolic models as platforms for construction of microbial proof-of-principle strains to direct new biological discovery in the field of industrial Biotechnology Bashir Sajo Mienda, Federal University Dutse, Nigeria
10.44 Flash presentation: Biotech Platform for Xylitol Production – A Tale of Metabolic Engineering and Intracellular Redox Balance Abhishek Somani, Aberystwyth University
10.52 Coffee
Session Six: Bioprocess Design
11:30 Bioprocess design: Bio-based methacrylates Gill Stephens, University of Nottingham
12 Rapid enzyme discovery and scale up Stuart West, Biocatalysts
12.2 Microbial production of Flavour and Fragrance isoprenoids Georg Lentzen, Isobionics BV
12.4 Flash Presentation: Exploration Yeasts as cell factories for production of add-value carboxylic acids and derivatives Nuno Mira, University of Lisbon
12.48 Flash Presentation: Design of mammalian cell factories by direct evolution Alejandro Fernandez-Martell, University of Sheffield
12.56 Flash Presentation: Developing yeast strains for biofuel production Naseem Guar, ICGEB, New Delhi
13.04 Flash Presentation: Engineering bacteria for isoprene biosynthesis Naglis Malys, University of Nottingham
13.15 Lunch
Session Seven: Technologies for rapid cell factory engineering
14.15 Technologies for rapid cell factory engineering John Heap, ICL
14:45 Metabolic engineering of Thermophiles and genetic tools Gudmundur Oli Hreggvidsson, Matis
15:15 Flash Presentation: Serine Integrase Recombinational Assembly (SIRA) for rapid multipart DNA assembly and rearrangement Femi Olorunniji, Liverpool John Moores University
15:23 Flash Presentation: The importance of information technology in bio-manufacturing Richard Kitney, Imperial College London
Session Eight: LCA, Techno-economic feasibility, RRI
15:30 Techno-economic and life cycle environmental aspects of bio-based products Jon McKechnie, University of Nottingham
16:00 Mobilising ideas of responsible innovation Susan Molyneux-Hodgson,  University of Exeter
16:20 Flash Presentation: Business services for SMEs in the bioeconomy: BioBase4SME and SuperBIO Lucy Montgomery, NNFCC
16:28 Concluding remarks
16:45 Close