Digesting New Elements in Peptide Transport

In mammals, the uptake of diet-derived di- and tri-peptides, as well as pharmaceutically important drug molecules such as antibiotics and anti-viral medications, is mediated by PepT1 and PepT2, members of the conserved proton-dependent oligopeptide transporter (POT) family. The POT family belongs to the major facilitator superfamily (MFS), members of which contain 12 transmembrane (TM) helices that form two domains each containing six TM helices related by a pseudo two-fold symmetry.

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