CSIRO Postdoctoral Fellowship – Designing Novel Transport Proteins for Synthetic Biology

CSIRO Postdoctoral Fellowship – Designing Novel Transport Proteins for Synthetic Biology

The Position

Postdoctoral Fellowships at CSIRO provide opportunities to scientists and engineers, who have completed their doctorate and have less than three years relevant postdoctoral work experience. These fellowships will help launch their careers, provide experience that will enhance their career prospects, and facilitate the recruitment and development of potential leaders for CSIRO.

Postdoctoral Fellows are appointed for up to three years and will work closely with a leading Research Scientist or Engineer in their respective field. They carry out innovative, impactful research of strategic importance to CSIRO with the possibility of novel and important scientific outcomes. They present the findings in appropriate publications and at conferences.

CSIRO is seeking to appoint a highly motivated Postdoctoral Fellow in the Biocatalysis Team in the area of membrane protein biochemistry working at the intersections of biochemistry, molecular biology, structural biology and synthetic biology. You will join a dynamic, multi-institutional, multi-disciplinary research team and will be challenged with the task of developing the design principles for modifying the specificity and selectivity of transporter proteins to develop new functional components for use in synthetic biology. This project provides an opportunity to help develop a new, state-of-the-art research program in CSIRO.

Specifically you will:

· Under the direction of senior research scientists, carry out innovative, impactful research of strategic importance to CSIRO that will, where possible, lead to novel and important scientific outcomes.
· Collaborate within CSIRO and with external partners to bring together the expertise and develop an innovative synthetic protein handle research program. Facilitate cross-fertilization between the biochemistry, molecular biology, synthetic biology and structural biology laboratories involved in the project.

· Develop a deep understanding of the molecular mechanisms and determinants of selectivity and specificity in transporter proteins using phylogenetics and bioinformatics approaches, state-of-the art techniques to obtain three-dimensional X-ray crystal structures from membrane proteins and mutagenesis studies.

· Use the insights gained to create bespoke ABC transporters for industrially relevant compounds.

· Use advanced synthetic biology technologies to integrate these transporters into chassis\production organisms, such as bacteria, yeast and algae & work with BD&C to develop a commercialisation plan for this technology.

· Undertake regular reviews of relevant literature and patents.

· Produce high quality scientific and/or engineering papers suitable for publication in quality journals, for client reports and granting of patents.

Location: Black Mountain, ACT, Australia
Salary: $81K – $88K plus up to 15.4% superannuation
Tenure: Specified term of 3 years
Reference: 18161


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