Post Doctoral Research Associate Positions Available Now

We are pleased to announce several Post Doctoral Research Associate Positions that are Available Now!


Post Doctoral Research Associate Position Available Now: Developing improved bacterial biocatalysts for sustainable chemical production. Starting 01/04/16, Based at The University of Sheffield

Applications are invited for an Post-doctoral Research Associate to join a multidisciplinary team focussing on developing improved bacterial biocatalysts for sustainable chemical production.

The position is part of a larger collaborative project, funded by BBSRC through the IB-Catalyst scheme, to understand how biotechnologically important bacteria are poisoned by desirable natural or engineered metabolic products that are of high commercial value. Product yields of many important industrial fermentations are limited by chemical (product) toxicity. We aim to gather extensive fundamental information using a range of cutting edge ‘omic’s-based techniques to learn how accumulation of these chemicals leads to severe cell stress and eventually death. The project (“DeTox”) will also engineer a variety of solutions into these strains to produce more tolerant versions.

The project is led from the University of York, with partners at the Universities of Cambridge, Nottingham and Sheffield and will use an integrative systems metabolic engineering strategy to identify and engineer solutions. The DeTox project offers an exciting opportunity to work across multiple sites and gain training in a wide range of techniques, while also working closely with our industrial partners during the course of the 5 year program.

Applicants will have a PhD degree in Microbiology/Biochemistry or a related subject (or have equivalent experience). The successful candidate is likely to have recent relevant research experience in bacterial fermentation processes, transcriptomics, molecular genetics and experience of working as part of a multidisciplinary team.

The post is fixed term for a period of 5 years with a start date of 1st April 2016.

Further information can be found here.


Post Doctoral Research Associate in Molecular Microbiology Position Available Now: Developing improved bacterial biocatalysts for sustainable chemical production. Starting 01/04/16, Based at The University of York

We are looking to recruit a highly motivated Postdoctoral Research Associate to join a multidisciplinary team focussing on developing improved bacterial biocatalysts for sustainable chemical production.  The position is part of a larger collaborative project, funded by BBSRC through the IB-Catalyst scheme, to understand how biotechnologically important bacteria are poisoned by desirable natural or engineered metabolic products that are of high commercial value. Product yields of many important industrial fermentations are limited by chemical (product) toxicity.  We aim to gather extensive fundamental information using a range of cutting edge ‘omic’s-based techniques to learn how accumulation of these chemicals leads to severe cell stress and eventually death. The project (“DeTox”) will also engineer a variety of solutions into these strains to produce more tolerant versions. The project is led by Dr. Gavin Thomas from the University of York, with partners at the Universities of Cambridge, Nottingham and Sheffield and will use an integrative systems metabolic engineering strategy to identify and engineer solutions. The DeTox project offers an exciting opportunity to work across multiple sites and gain training in a wide range of techniques, while also working closely with our industrial partners during the course of the 5 year program. You will work in the Thomas lab to use genetic and synthetic biology approaches to engineer traits that lead to improved chemical resistance into Escherichia coli and solventogenic Clostridia. This will include the biological characterisation of novel bacterial uptake and efflux systems in the membrane and novel synthetic biology approaches to fuse transporters with cytoplasmic enzymes.

You will have a PhD degree in Microbiology/Biochemistry or a related subject or be close to completion. You are likely to have recent relevant research experience in molecular genetics and molecular/synthetic biology. Previous work on bacterial transporters or membrane-related bacterial processes is desirable but not essential. Experience of working as part of a multidisciplinary team is also desirable.

This post is available for up to 60 months. Start date is 1st April 2016.

Further information can be found here.


Post-doctoral Research Associate in Bioinformatics Position Available Now: Developing improved bacterial biocatalysts for sustainable chemical production. Starting 01/04/16, Based at The University of York

We are looking to recruit a highly motivated Postdoctoral Research Associate to join a multidisciplinary team focussing on developing improved bacterial biocatalysts for sustainable chemical production.  The position is part of a larger collaborative project, funded by BBSRC through the IB-Catalyst scheme, to understand how biotechnologically important bacteria are poisoned by desirable natural or engineered metabolic products that are of high commercial value. Product yields of many important industrial fermentations are limited by chemical (product) toxicity.  We aim to gather extensive fundamental information using a range of cutting edge ‘omic’s-based techniques to learn how accumulation of these chemicals leads to severe cell stress and eventually death. The project (“DeTox”) will also engineer a variety of solutions into these strains to produce more tolerant versions. The project is led by Dr. Gavin Thomas from the University of York, with partners at the Universities of Cambridge, Nottingham and Sheffield and will use an integrative systems metabolic engineering strategy to identify and engineer solutions. The DeTox project offers an exciting opportunity to work across multiple sites and gain training in a wide range of techniques, while also working closely with our industrial partners during the course of the 5 year program. You will work in the Thomas lab and be the lead developer of DeToxBASE, the key bioinformatics resource for the project, which will integrate and provide analysis tools to interrogate the multiple data types emerging from the experimental program.  You will work closely with the experimental PDRAs to ensure the best integration of data and usefulness of the resource and to then analyse the data to discover holistic systems-based changes to cell behaviour upon toxin exposure.

You will already possess, or will be awarded a PhD in Bioinformations, Computational Biology or a related subject within six months of starting the post You are likely to have recent relevant research experience in data integration and analysis of ‘omics’ data types. Previous knowledge of bacteria physiology and biochemistry is desirable but not essential. Experience of working as part of a multidisciplinary team is also desirable.

This position is available as a 1.0 FTE for 36 months or a 0.6 FTE for up to 60 months and starts on the 1st April 2016.

Further information can be found here.


Post Doctoral Research Associate in Molecular Microbiology Position Available Now:  Molecular basis of body odour production by the human underarm microbiome. Starting 01/04/16, Based at The University of York

We are looking to recruit a highly motivated Postdoctoral Research Associate to join the group of Gavin Thomas to work on a project to elucidate the molecular basis of body odour production by the human underarm microbiome. In previous collaborative worth with Unilever, we have identified a small number of Staphyloccocal species that are responsible for the production of the thioalcohol component of body odour. You will be undertake a series of biochemical and genetic studies working with Staphylococci and its purified proteins to understand the molecular basis of malodour precursor uptake and subsequence metabolism, to provide significant insight into the molecular mechanism behind the formation of human body odour.  You will be an experienced microbiologist or biochemist who has worked with purification and assay of recombinant proteins and ideally also with membrane transporter proteins. The project will involved the reconstitution and in vitro assay of membrane transporters as well as the biochemical characterisation of a number of soluble enzymes. The project will also work directly on the Staphylococci to create strains deficient in malodour production and so you will ideally have experience in microbiology and microbial genetics.

This exciting project is funded by the BBSRC LINK scheme, and has a parallel researcher working on related aspects of malodour production under the supervision of Dr Gordon James in Unilever. You will work collaboratively with Unilever on some of the project objectives. You will join a large active and dynamic research community in molecular microbiology in the York Biology department.

You will have a PhD degree in Microbiology/Biochemistry or a related subject or be close to completion.  You are likely to have recent relevant research experience in enzyme characterisation and ideally worked with membrane proteins, although this is not essential. Some experience of bacterial genetics is also desirable.

The post is fixed term for a period of up to 36 months with a start date of 1st April 2016.

Further information can be found here.

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