Category Archives: Uncategorized

CBMNet proud to be sponsoring Membrane Proteins From A to Z: Symposium around the life and work of Prof Baldwin

CBMNet proud to be sponsoring Membrane Proteins From A to Z: Symposium around the life and work of Prof Baldwin

Colleagues from around the world will be travelling to the University of Leeds to discuss and celebrate the wonderful contributions that Steve made to the field of Biochemistry and specifically membrane protein structure and function.

This two day symposium will include a lecture from Nobel Laureate Prof. Sir John Walker FRS.

For more information on this event please see http://www.fbs.leeds.ac.uk/baldwin/

CBMNet is proud to be sponsoring session three on day one of the event – a session all about membrane transporter proteins.

We also have Grants available to pay for Early Career Researchers to attend this event. For more information on the grants please see http://cbmnetnibb.group.shef.ac.uk/funding/travel-grants/

 

SCIENCE: Engineering alcohol tolerance in yeast

ABSTRACT:
Ethanol toxicity in the yeast Saccharomyces cerevisiae limits titer and productivity in the industrial production of transportation bioethanol. We show that strengthening the opposing potassium and proton electrochemical membrane gradients is a mechanism that enhances general resistance to multiple alcohols. The elevation of extracellular potassium and pH physically bolsters these gradients, increasing tolerance to higher alcohols and ethanol fermentation in commercial and laboratory strains (including a xylose-fermenting strain) under industrial-like conditions. Production per cell remains largely unchanged, with improvements deriving from heightened population viability. Likewise, up-regulation of the potassium and proton pumps in the laboratory strain enhances performance to levels exceeding those of industrial strains. Although genetically complex, alcohol tolerance can thus be dominated by a single cellular process, one controlled by a major physicochemical component but amenable to biological augmentation.

Read more here.

Recent Entries »